| 9/1/2022 | Eastern New Mexico (3-8) | 34 | at | New Mexico Highlands | 18 | LSC | ||
| 9/17/2022 | Fort Lewis (0-10,0-9) | 3 | at | New Mexico Highlands | 27 | |||
| 9/24/2022 | New Mexico Highlands | 27 | at | South Dakota Tech (7-4,6-3) | 41 | |||
| 10/1/2022 | New Mexico Highlands | 23 | at | Adams State (2-9,2-7) | 21 | |||
| 10/8/2022 | Black Hills State (7-4,5-4) | 28 | at | New Mexico Highlands | 30 | |||
| 10/15/2022 | New Mexico Highlands | 11 | at | Colorado State-Pueblo (8-4,7-3) | 35 | |||
| 10/22/2022 | Western Colorado (7-4,7-2) | 30 | at | New Mexico Highlands | 13 | |||
| 10/29/2022 | New Mexico Highlands | 3 | at | Chadron State (3-8,3-6) | 17 | |||
| 11/5/2022 | Colorado Mines (13-3,10-0) | 54 | at | New Mexico Highlands | 16 | |||
| 11/12/2022 | New Mexico Highlands | 36 | at | Colorado Mesa (4-6,3-6) | 56 |
| vs New Mexico Highlands | vs Other Opponents | New Mexico Highlands compared to OOs | |
| Record: | 7-3 | 47-57 | |
| Points Scored: | 31.90 | 28.45 | -3.45 |
| Points Allowed: | 20.40 | 30.82 | -10.42 |
| Margin: | 11.50 | -2.37 | -13.87 |
| Total Points: | 52.30 | 59.27 | -6.97 |