| 9/3/2022 | Western Colorado | 6 | at | West Texas A&M (5-6) | 44 | at LSC | ||
| 9/10/2022 | Western Colorado | 31 | at | Texas-Permian Basin (5-6) | 34 | at LSC | ||
| 9/17/2022 | Western Colorado | 17 | at | Colorado State-Pueblo (8-4,7-3) | 10 | |||
| 9/24/2022 | Chadron State (3-8,3-6) | 28 | at | Western Colorado | 56 | |||
| 10/1/2022 | Western Colorado | 42 | at | Colorado Mesa (4-6,3-6) | 34 | 2OT | ||
| 10/8/2022 | South Dakota Tech (7-4,6-3) | 38 | at | Western Colorado | 10 | |||
| 10/15/2022 | Western Colorado | 28 | at | Black Hills State (7-4,5-4) | 27 | |||
| 10/22/2022 | Western Colorado | 30 | at | New Mexico Highlands (3-7,3-6) | 13 | |||
| 10/29/2022 | Colorado Mines (13-3,10-0) | 30 | at | Western Colorado | 20 | |||
| 11/5/2022 | Western Colorado | 55 | at | Fort Lewis (0-10,0-9) | 14 | |||
| 11/12/2022 | Adams State (2-9,2-7) | 10 | at | Western Colorado | 52 |
| vs Western Colorado | vs Other Opponents | Western Colorado compared to OOs | |
| Record: | 4-7 | 53-60 | |
| Points Scored: | 25.64 | 28.42 | 2.78 |
| Points Allowed: | 31.55 | 29.67 | 1.88 |
| Margin: | -5.91 | -1.25 | 4.66 |
| Total Points: | 57.19 | 58.09 | -0.90 |