| 9/1/2022 | East Stroudsburg | 16 | at | Pace (6-4) | 31 | at NE10 | ||
| 9/10/2022 | Indiana PA (10-2,9-2) | 38 | at | East Stroudsburg | 35 | |||
| 9/17/2022 | East Stroudsburg | 22 | at | Seton Hill (2-9,2-8) | 7 | |||
| 9/24/2022 | Lock Haven (1-10,0-10) | 7 | at | East Stroudsburg | 48 | |||
| 10/1/2022 | Kutztown (8-3,8-2) | 24 | at | East Stroudsburg | 20 | |||
| 10/8/2022 | East Stroudsburg | 14 | at | Millersville (5-6,5-5) | 20 | |||
| 10/15/2022 | West Chester (7-4,6-4) | 24 | at | East Stroudsburg | 21 | |||
| 10/22/2022 | East Stroudsburg | 27 | at | Bloomsburg (4-7,4-6) | 21 | |||
| 10/29/2022 | East Stroudsburg | 23 | at | Shippensburg (5-6,5-5) | 16 | |||
| 11/5/2022 | Shepherd (13-2,11-1) | 37 | at | East Stroudsburg | 14 | |||
| 11/12/2022 | East Stroudsburg | 7 | at | California PA (6-5,5-5) | 31 |
| vs East Stroudsburg | vs Other Opponents | East Stroudsburg compared to OOs | |
| Record: | 7-4 | 60-54 | |
| Points Scored: | 23.27 | 24.39 | 1.12 |
| Points Allowed: | 22.45 | 22.99 | -0.54 |
| Margin: | 0.82 | 1.40 | 0.58 |
| Total Points: | 45.72 | 47.38 | -1.66 |