| 9/3/2022 | Shippensburg (5-6) | 6 | at | West Virginia State | 29 | | | PSAC |
| 9/10/2022 | West Virginia State | 7 | at | Frostburg State (8-3,7-3) | 18 | | | |
| 9/17/2022 | Fairmont State (3-8,3-7) | 29 | at | West Virginia State | 34 | | | |
| 9/24/2022 | Notre Dame OH (9-3,9-1) | 48 | at | West Virginia State | 13 | | | |
| 10/1/2022 | West Virginia State | 30 | at | Alderson-Broaddus (0-11,0-10) | 3 | | | |
| 10/8/2022 | West Virginia Wesleyan (1-10,1-9) | 21 | at | West Virginia State | 46 | | | |
| 10/13/2022 | West Virginia State | 24 | at | UNC Pembroke (5-6,5-5) | 45 | | | |
| 10/22/2022 | Concord (9-2,8-2) | 38 | at | West Virginia State | 56 | | | |
| 10/29/2022 | West Virginia State | 30 | at | Glenville State (7-4,6-4) | 31 | | | |
| 11/5/2022 | West Liberty (4-7,3-7) | 32 | at | West Virginia State | 42 | | | |
| 11/12/2022 | West Virginia State | 42 | at | Charleston WV (6-5,6-4) | 35 | | | |