| 9/1/2022 | Chadron State (3-8) | 0 | at | Angelo State | 35 | RMAC | ||
| 9/10/2022 | Angelo State | 30 | at | Colorado Mines (13-3) | 27 | OT | at RMAC | |
| 9/17/2022 | Angelo State | 34 | at | Texas-Permian Basin (5-6,4-5) | 21 | |||
| 9/24/2022 | West Texas A&M (5-6,3-6) | 14 | at | Angelo State | 34 | |||
| 10/1/2022 | Angelo State | 30 | at | Western Oregon (6-5,5-4) | 7 | |||
| 10/8/2022 | Eastern New Mexico (3-8,2-7) | 9 | at | Angelo State | 28 | |||
| 10/15/2022 | Angelo State | 52 | at | Western New Mexico (6-5,5-4) | 13 | |||
| 10/22/2022 | Texas A&M-Kingsville (7-5,5-4) | 7 | at | Angelo State | 34 | |||
| 10/29/2022 | Angelo State | 24 | at | Simon Fraser (1-8,1-8) | 0 | |||
| 11/5/2022 | Central Washington (6-4,6-3) | 12 | at | Angelo State | 22 | |||
| 11/12/2022 | Angelo State | 37 | at | Midwestern State (6-5,5-4) | 19 | |||
| 11/26/2022 | Bemidji State (10-3) | 7 | at | Angelo State | 33 | D2 Playoffs Round 2 | NSIC | |
| 12/3/2022 | Colorado Mines (13-3) | 42 | at | Angelo State | 24 | D2 Quarterfinals | RMAC |
| vs Angelo State | vs Other Opponents | Angelo State compared to OOs | |
| Record: | 1-12 | 82-56 | |
| Points Scored: | 13.69 | 31.82 | 18.13 |
| Points Allowed: | 32.08 | 24.70 | 7.38 |
| Margin: | -18.39 | 7.12 | 25.51 |
| Total Points: | 45.77 | 56.52 | -10.75 |