| 9/2/2022 | Dean | 28 | at | Fitchburg State | 33 | ECFC | ||
| Nichols | 30 | at | Westfield State | 29 | CCF | |||
| Worcester Polytechnic | 58 | at | Worcester State | 21 | NEWMAC | |||
| 9/3/2022 | Ithaca | 51 | at | Bridgewater State MA | 14 | LL | ||
| Framingham State | 7 | at | Brockport State | 27 | @ E8 | |||
| Castleton State | 7 | at | Plymouth State | 20 | ECFC | |||
| Husson | 14 | at | UMass Dartmouth | 35 | CCF | |||
| Western Connecticut | 7 | at | William Paterson | 28 | @ NJAC | |||
| 9/9/2022 | Massachusetts Maritime | 14 | at | SUNY-Maritime | 17 | @ ECFC | ||
| 9/10/2022 | Western Connecticut | 28 | at | Albright | 14 | @ MidAC | ||
| UMass Dartmouth | 48 | at | Anna Maria | 63 | @ ECFC | |||
| Fitchburg State | 0 | at | Castleton State | 48 | @ ECFC | |||
| St John Fisher | 20 | at | Framingham State | 31 | E8 | |||
| Plymouth State | 17 | at | Husson | 0 | @ CCF | |||
| Bridgewater State MA | 23 | at | University of New England | 38 | @ CCF | |||
| Worcester State | 7 | at | Union NY | 76 | @ LL | |||
| Westfield State | 14 | at | Western New England | 38 | @ CCF | |||
| 9/16/2022 | Western Connecticut | 34 | at | Westfield State | 20 | |||
| 9/17/2022 | Worcester State | 56 | at | Fitchburg State | 10 | |||
| Anna Maria | 23 | at | Massachusetts Maritime | 14 | ECFC | |||
| Bridgewater State MA | 34 | at | Plymouth State | 41 | ||||
| Framingham State | 21 | at | UMass Dartmouth | 46 | ||||
| 9/24/2022 | Massachusetts Maritime | 38 | at | Fitchburg State | 13 | |||
| Bridgewater State MA | 40 | at | Western Connecticut | 27 | ||||
| Framingham State | 14 | at | Westfield State | 11 | ||||
| UMass Dartmouth | 41 | at | Worcester State | 20 | ||||
| 9/30/2022 | Western Connecticut | 21 | at | UMass Dartmouth | 48 | |||
| 10/1/2022 | Fitchburg State | 0 | at | Bridgewater State MA | 82 | |||
| Plymouth State | 14 | at | Framingham State | 9 | ||||
| Westfield State | 9 | at | Massachusetts Maritime | 20 | ||||
| 10/6/2022 | UMass Dartmouth | 28 | at | Massachusetts Maritime | 14 | |||
| 10/8/2022 | Worcester State | 0 | at | Bridgewater State MA | 45 | |||
| Fitchburg State | 0 | at | Framingham State | 47 | ||||
| Western Connecticut | 34 | at | Plymouth State | 27 | ||||
| 10/15/2022 | Plymouth State | 42 | at | Fitchburg State | 7 | |||
| Westfield State | 7 | at | UMass Dartmouth | 34 | ||||
| Framingham State | 14 | at | Western Connecticut | 35 | ||||
| Massachusetts Maritime | 25 | at | Worcester State | 17 | ||||
| 10/22/2022 | UMass Dartmouth | 49 | at | Fitchburg State | 0 | |||
| Western Connecticut | 24 | at | Massachusetts Maritime | 3 | ||||
| Bridgewater State MA | 42 | at | Westfield State | 7 | ||||
| Plymouth State | 56 | at | Worcester State | 21 | ||||
| 10/29/2022 | Massachusetts Maritime | 10 | at | Framingham State | 34 | |||
| Westfield State | 22 | at | Plymouth State | 31 | ||||
| Bridgewater State MA | 7 | at | UMass Dartmouth | 48 | ||||
| Worcester State | 35 | at | Western Connecticut | 38 | ||||
| 11/5/2022 | Framingham State | 19 | at | Bridgewater State MA | 20 | |||
| Plymouth State | 21 | at | Massachusetts Maritime | 7 | ||||
| Fitchburg State | 21 | at | Western Connecticut | 41 | ||||
| Westfield State | 28 | at | Worcester State | 18 | ||||
| 11/11/2022 | Worcester State | 16 | at | Framingham State | 21 | |||
| 11/12/2022 | Massachusetts Maritime | 0 | at | Bridgewater State MA | 10 | |||
| UMass Dartmouth | 46 | at | Plymouth State | 21 | ||||
| Fitchburg State | 0 | at | Westfield State | 50 | ||||
| 11/19/2022 | Catholic | 24 | at | Bridgewater State MA | 34 | New England Bowl | NEWMAC | |
| Plymouth State | 21 | at | Husson | 20 | New England Bowl | @ CCF | ||
| UMass Dartmouth | 20 | at | Ithaca | 63 | D3 Championship Round 1 | @ LL |