| 9/4/2021 | Utica | 39 | at | Alfred State | 21 | E8 | ||
| Plymouth State | 0 | at | Castleton State | 13 | MSCAC | |||
| Fitchburg State | 6 | at | Dean | 42 | MSCAC | |||
| Keystone | 7 | at | Wilkes | 46 | @ MidAC | |||
| 9/10/2021 | SUNY-Maritime | 6 | at | Massachusetts Maritime | 14 | @ MSCAC | ||
| 9/11/2021 | Nichols | 27 | at | Anna Maria | 23 | CCF | ||
| Castleton State | 35 | at | Fitchburg State | 0 | @ MSCAC | |||
| Misericordia | 28 | at | Keystone | 7 | MidAC | |||
| Alfred State | 27 | at | Rochester | 28 | @ LL | |||
| Dean | 29 | at | UMass Dartmouth | 48 | @ MSCAC | |||
| 9/17/2021 | Dean | 14 | at | Husson | 42 | @ CCF | ||
| 9/18/2021 | University of New England | 20 | at | Alfred State | 17 | CCF | ||
| Massachusetts Maritime | 13 | at | Anna Maria | 23 | MSCAC | |||
| Norwich | 28 | at | Castleton State | 12 | NEWMAC | |||
| William Paterson | 42 | at | Keystone | 14 | NJAC | |||
| Merchant Marine | 56 | at | SUNY-Maritime | 7 | NEWMAC | |||
| 9/25/2021 | Anna Maria | 29 | at | Coast Guard | 24 | @ NEWMAC | ||
| MIT | 27 | at | Dean | 0 | NEWMAC | |||
| Alfred State | 35 | at | Defiance | 28 | @ HCA | |||
| Gallaudet | 49 | at | Greensboro | 42 | @ USASC | |||
| Keystone | 14 | at | Hobart | 58 | @ LL | |||
| Castleton State | 3 | at | St Lawrence | 55 | @ LL | |||
| SUNY-Maritime | 7 | at | William Paterson | 28 | @ NJAC | |||
| 10/2/2021 | Dean | 35 | at | Gallaudet | 42 | |||
| Anna Maria | 55 | at | Keystone | 35 | ||||
| Castleton State | 16 | at | SUNY-Maritime | 19 | ||||
| 10/9/2021 | SUNY-Maritime | 20 | at | Alfred State | 35 | |||
| Castleton State | 21 | at | Dean | 13 | ||||
| Keystone | 14 | at | Gallaudet | 34 | ||||
| 10/16/2021 | Anna Maria | 28 | at | Alfred State | 17 | |||
| Dean | 39 | at | Keystone | 36 | ||||
| Gallaudet | 23 | at | SUNY-Maritime | 9 | ||||
| 10/23/2021 | Dean | 32 | at | Anna Maria | 45 | |||
| Keystone | 0 | at | Castleton State | 41 | ||||
| Alfred State | 24 | at | Gallaudet | 21 | ||||
| 10/30/2021 | Anna Maria | 31 | at | Castleton State | 38 | |||
| SUNY-Maritime | 31 | at | Dean | 27 | ||||
| Alfred State | 38 | at | Keystone | 7 | ||||
| 11/6/2021 | Castleton State | 24 | at | Alfred State | 35 | |||
| Gallaudet | 21 | at | Anna Maria | 37 | ||||
| Keystone | 21 | at | SUNY-Maritime | 24 | ||||
| 11/13/2021 | SUNY-Maritime | 7 | at | Anna Maria | 31 | |||
| Gallaudet | 30 | at | Castleton State | 31 | ||||
| Alfred State | 37 | at | Dean | 15 | ||||
| 11/20/2021 | Anna Maria | 10 | at | Delaware Valley | 62 | @ MidAC | ||
| Alfred State | 16 | at | UMass Dartmouth | 42 | @ MSCAC |