| 9/4/2021 | Fitchburg State | 6 | at | Dean (2-8) | 42 | at ECFC | ||
| 9/11/2021 | Castleton State (6-4) | 35 | at | Fitchburg State | 0 | ECFC | ||
| 9/18/2021 | Fitchburg State | 35 | at | Worcester State (3-7,3-5) | 38 | |||
| 9/25/2021 | Fitchburg State | 0 | at | Massachusetts Maritime (4-6,3-5) | 28 | |||
| 10/2/2021 | Bridgewater State MA (6-4,6-2) | 42 | at | Fitchburg State | 0 | |||
| 10/9/2021 | Framingham State (8-3,8-0) | 35 | at | Fitchburg State | 0 | |||
| 10/16/2021 | Fitchburg State | 0 | at | Plymouth State (5-5,5-3) | 36 | |||
| 10/23/2021 | Fitchburg State | 0 | at | UMass Dartmouth (9-2,6-2) | 40 | |||
| 11/6/2021 | Western Connecticut (5-5,4-4) | 48 | at | Fitchburg State | 13 | |||
| 11/13/2021 | Westfield State (1-9,1-7) | 38 | at | Fitchburg State | 20 |
| vs Fitchburg State | vs Other Opponents | Fitchburg State compared to OOs | |
| Record: | 10-0 | 39-53 | |
| Points Scored: | 38.20 | 22.05 | -16.15 |
| Points Allowed: | 7.40 | 26.15 | -18.75 |
| Margin: | 30.80 | -4.10 | -34.90 |
| Total Points: | 45.60 | 48.20 | -2.60 |