| 9/4/2021 | UMass Dartmouth | 21 | at | Husson (7-3) | 14 | at CCF | ||
| 9/11/2021 | Dean (2-8) | 29 | at | UMass Dartmouth | 48 | ECFC | ||
| 9/18/2021 | UMass Dartmouth | 21 | at | Framingham State (8-3,8-0) | 45 | |||
| 9/25/2021 | Worcester State (3-7,3-5) | 7 | at | UMass Dartmouth | 52 | |||
| 10/2/2021 | UMass Dartmouth | 19 | at | Western Connecticut (5-5,4-4) | 34 | |||
| 10/9/2021 | Massachusetts Maritime (4-6,3-5) | 10 | at | UMass Dartmouth | 26 | |||
| 10/16/2021 | UMass Dartmouth | 26 | at | Westfield State (1-9,1-7) | 16 | |||
| 10/23/2021 | Fitchburg State (0-10,0-8) | 0 | at | UMass Dartmouth | 40 | |||
| 10/30/2021 | UMass Dartmouth | 26 | at | Bridgewater State MA (6-4,6-2) | 20 | |||
| 11/13/2021 | Plymouth State (5-5,5-3) | 7 | at | UMass Dartmouth | 28 | |||
| 11/20/2021 | Alfred State (6-5) | 16 | at | UMass Dartmouth | 42 | ECFC |
| vs UMass Dartmouth | vs Other Opponents | UMass Dartmouth compared to OOs | |
| Record: | 2-9 | 45-56 | |
| Points Scored: | 18.00 | 22.03 | 4.03 |
| Points Allowed: | 31.73 | 25.23 | 6.50 |
| Margin: | -13.73 | -3.20 | 10.53 |
| Total Points: | 49.73 | 47.26 | 2.47 |