| 9/4/2021 | Southern Virginia | 41 | at | Wilmington (2-7) | 34 | OT | at OAC | |
| 9/11/2021 | Bridgewater VA (4-6,2-5) | 35 | at | Southern Virginia | 17 | |||
| 9/18/2021 | LaGrange (2-8) | 38 | at | Southern Virginia | 34 | USASC | ||
| 9/25/2021 | Southern Virginia | 14 | at | Methodist (7-2) | 37 | at USASC | ||
| 10/2/2021 | Southern Virginia | 17 | at | Maryville (4-6) | 38 | at USASC | ||
| 10/9/2021 | Huntingdon AL (8-3) | 48 | at | Southern Virginia | 20 | USASC | ||
| 10/16/2021 | Greensboro (0-10) | 14 | at | Southern Virginia | 31 | USASC | ||
| 10/23/2021 | Southern Virginia | 3 | at | Brevard (6-4) | 7 | at USASC | ||
| 10/30/2021 | Averett (5-5,1-1) | 28 | at | Southern Virginia | 23 | |||
| 11/6/2021 | Southern Virginia | 10 | at | North Carolina Wesleyan (4-6) | 19 | at USASC |
| vs Southern Virginia | vs Other Opponents | Southern Virginia compared to OOs | |
| Record: | 8-2 | 34-55 | |
| Points Scored: | 29.80 | 22.40 | -7.40 |
| Points Allowed: | 21.00 | 27.45 | -6.45 |
| Margin: | 8.80 | -5.05 | -13.85 |
| Total Points: | 50.80 | 49.85 | 0.95 |