| 9/4/2021 | Northwestern MN | 0 | at | Wheaton (10-2) | 56 | at CCIW | ||
| 9/11/2021 | Buena Vista (5-5) | 58 | at | Northwestern MN | 21 | ARC | ||
| 9/18/2021 | Wisconsin-River Falls (9-2) | 71 | at | Northwestern MN | 13 | WIAC | ||
| 9/25/2021 | Northwestern MN | 10 | at | Hope (8-2) | 52 | at MIAA | ||
| 10/2/2021 | Finlandia (0-9) | 13 | at | Northwestern MN | 16 | MIAA | ||
| 10/9/2021 | Northwestern MN | 23 | at | Greenville (8-3,5-0) | 35 | |||
| 10/23/2021 | Westminster MO (3-5,1-4) | 28 | at | Northwestern MN | 45 | |||
| 10/30/2021 | Northwestern MN | 21 | at | Minnesota-Morris (5-5,4-2) | 28 | |||
| 11/6/2021 | Crown (1-9,0-6) | at | Northwestern MN | Postponed | ||||
| 11/13/2021 | Northwestern MN | 21 | at | Martin Luther (5-4,4-1) | 27 | |||
| 11/17/2021 | Crown (1-9,0-6) | 20 | at | Northwestern MN | 59 |
| vs Northwestern MN | vs Other Opponents | Northwestern MN compared to OOs | |
| Record: | 7-3 | 48-51 | |
| Points Scored: | 38.80 | 30.90 | -7.90 |
| Points Allowed: | 22.90 | 31.74 | -8.84 |
| Margin: | 15.90 | -0.84 | -16.74 |
| Total Points: | 61.70 | 62.64 | -0.94 |