| 9/4/2021 | Washington U | 21 | at | Chicago (8-2) | 31 | at MidW | ||
| 9/18/2021 | North Park (2-8,2-7) | 7 | at | Washington U | 41 | |||
| 9/25/2021 | Elmhurst (1-9,1-8) | 7 | at | Washington U | 27 | |||
| 10/2/2021 | Wheaton (10-2,8-1) | 40 | at | Washington U | 10 | |||
| 10/9/2021 | Illinois Wesleyan (3-7,3-6) | 22 | at | Washington U | 38 | |||
| 10/16/2021 | Washington U | 31 | at | Augustana IL (5-5,4-5) | 7 | |||
| 10/23/2021 | Washington U | 55 | at | Millikin (3-7,3-6) | 13 | |||
| 10/30/2021 | Carroll WI (6-4,5-4) | 12 | at | Washington U | 35 | |||
| 11/6/2021 | North Central (13-1,9-0) | 59 | at | Washington U | 20 | |||
| 11/13/2021 | Washington U | 37 | at | Carthage (3-7,3-6) | 16 | |||
| 11/20/2021 | Washington U | 27 | vs | Wisconsin-River Falls (9-2) | 48 | Verona WI | vs WIAC |
| vs Washington U | vs Other Opponents | Washington U compared to OOs | |
| Record: | 4-7 | 59-47 | |
| Points Scored: | 23.82 | 33.16 | 9.34 |
| Points Allowed: | 31.09 | 27.99 | 3.10 |
| Margin: | -7.27 | 5.17 | 12.44 |
| Total Points: | 54.91 | 61.15 | -6.24 |