| 9/4/2021 | Methodist (7-2) | 23 | at | Shenandoah | 28 | USASC | ||
| 9/11/2021 | Shenandoah | 30 | at | North Carolina Wesleyan (4-6) | 21 | at USASC | ||
| 9/18/2021 | Shenandoah | 7 | at | Hampden-Sydney (5-5,4-2) | 28 | |||
| 10/2/2021 | Bridgewater VA (4-6,2-5) | 27 | at | Shenandoah | 34 | |||
| 10/9/2021 | Shenandoah | 52 | at | Guilford (1-7,0-6) | 25 | |||
| 10/16/2021 | Shenandoah | 23 | at | Ferrum (6-4,4-3) | 24 | |||
| 10/23/2021 | Emory & Henry (6-4) | 7 | at | Shenandoah | 9 | D2Ind (D2) | ||
| 10/30/2021 | Shenandoah | 14 | at | Randolph-Macon (9-1,5-1) | 45 | |||
| 11/6/2021 | Apprentice (1-7) | 16 | at | Shenandoah | 35 | None (Unk?) | ||
| 11/13/2021 | Washington and Lee (8-3,5-1) | 6 | at | Shenandoah | 14 |
| vs Shenandoah | vs Other Opponents | Shenandoah compared to OOs | |
| Record: | 3-7 | 48-38 | |
| Points Scored: | 22.20 | 27.66 | 5.46 |
| Points Allowed: | 24.60 | 25.77 | -1.17 |
| Margin: | -2.40 | 1.89 | 4.29 |
| Total Points: | 46.80 | 53.43 | -6.63 |