| 9/4/2021 | Waynesburg | 6 | at | Muskingum (5-5) | 49 | at OAC | ||
| 9/11/2021 | Case Western Reserve (6-4,5-4) | 66 | at | Waynesburg | 33 | |||
| 9/18/2021 | Thiel (0-10,0-9) | 14 | at | Waynesburg | 52 | |||
| 9/25/2021 | Waynesburg | 3 | at | Carnegie Mellon (8-2,8-1) | 39 | |||
| 10/2/2021 | Grove City (8-3,6-3) | 38 | at | Waynesburg | 0 | |||
| 10/16/2021 | Waynesburg | 14 | at | Westminster PA (8-3,8-1) | 66 | |||
| 10/23/2021 | St Vincent (5-6,4-5) | 38 | at | Waynesburg | 7 | |||
| 10/30/2021 | Waynesburg | 3 | at | Geneva (4-6,4-5) | 49 | |||
| 11/6/2021 | Bethany WV (1-9,1-8) | 7 | at | Waynesburg | 31 | |||
| 11/13/2021 | Waynesburg | 0 | at | Washington & Jefferson (8-3,7-2) | 55 |
| vs Waynesburg | vs Other Opponents | Waynesburg compared to OOs | |
| Record: | 8-2 | 45-49 | |
| Points Scored: | 42.10 | 25.32 | -16.78 |
| Points Allowed: | 14.90 | 26.83 | -11.93 |
| Margin: | 27.20 | -1.51 | -28.71 |
| Total Points: | 57.00 | 52.15 | 4.85 |