| 9/4/2021 | Thiel | 14 | at | Allegheny (3-7) | 42 | at NCA | ||
| 9/11/2021 | Washington & Jefferson (8-3,7-2) | 64 | at | Thiel | 12 | |||
| 9/18/2021 | Thiel | 14 | at | Waynesburg (2-8,2-7) | 52 | |||
| 9/25/2021 | St Vincent (5-6,4-5) | 41 | at | Thiel | 7 | |||
| 10/2/2021 | Westminster PA (8-3,8-1) | 49 | at | Thiel | 14 | |||
| 10/9/2021 | Thiel | 7 | at | Bethany WV (1-9,1-8) | 28 | |||
| 10/23/2021 | Thiel | 0 | at | Carnegie Mellon (8-2,8-1) | 53 | |||
| 10/30/2021 | Case Western Reserve (6-4,5-4) | 30 | at | Thiel | 12 | |||
| 11/6/2021 | Thiel | 0 | at | Geneva (4-6,4-5) | 49 | |||
| 11/13/2021 | Grove City (8-3,6-3) | 56 | at | Thiel | 0 |
| vs Thiel | vs Other Opponents | Thiel compared to OOs | |
| Record: | 10-0 | 43-51 | |
| Points Scored: | 46.40 | 25.56 | -20.84 |
| Points Allowed: | 8.00 | 27.14 | -19.14 |
| Margin: | 38.40 | -1.58 | -39.98 |
| Total Points: | 54.40 | 52.70 | 1.70 |