| 9/3/2021 | Carnegie Mellon | 10 | at | Whitworth (7-3) | 13 | at NWC | ||
| 9/11/2021 | Carnegie Mellon | 31 | at | Geneva (4-6,4-5) | 17 | |||
| 9/18/2021 | Carnegie Mellon | 6 | at | Grove City (8-3,6-3) | 13 | |||
| 9/25/2021 | Waynesburg (2-8,2-7) | 3 | at | Carnegie Mellon | 39 | |||
| 10/2/2021 | Carnegie Mellon | 47 | at | Bethany WV (1-9,1-8) | 7 | |||
| 10/9/2021 | Westminster PA (8-3,8-1) | 10 | at | Carnegie Mellon | 34 | |||
| 10/23/2021 | Thiel (0-10,0-9) | 0 | at | Carnegie Mellon | 53 | |||
| 10/30/2021 | Carnegie Mellon | 34 | at | St Vincent (5-6,4-5) | 7 | |||
| 11/6/2021 | Washington & Jefferson (8-3,7-2) | 11 | at | Carnegie Mellon | 27 | |||
| 11/13/2021 | Case Western Reserve (6-4,5-4) | 6 | at | Carnegie Mellon | 24 | |||
| 11/20/2021 | Carnegie Mellon | at | North Central (13-1) | Cancelled | at CCIW |
| vs Carnegie Mellon | vs Other Opponents | Carnegie Mellon compared to OOs | |
| Record: | 2-8 | 60-48 | |
| Points Scored: | 8.70 | 30.87 | 22.17 |
| Points Allowed: | 30.50 | 25.69 | 4.81 |
| Margin: | -21.80 | 5.18 | 26.98 |
| Total Points: | 39.20 | 56.56 | -17.36 |