| 9/3/2021 | Bethany WV | 21 | at | Hiram (1-9) | 41 | at NCA | ||
| 9/11/2021 | Bethany WV | 15 | at | Grove City (8-3,6-3) | 48 | |||
| 9/18/2021 | Bethany WV | 3 | at | Washington & Jefferson (8-3,7-2) | 28 | |||
| 9/25/2021 | Geneva (4-6,4-5) | 42 | at | Bethany WV | 7 | |||
| 10/2/2021 | Carnegie Mellon (8-2,8-1) | 47 | at | Bethany WV | 7 | |||
| 10/9/2021 | Thiel (0-10,0-9) | 7 | at | Bethany WV | 28 | |||
| 10/16/2021 | Bethany WV | 0 | at | Case Western Reserve (6-4,5-4) | 53 | |||
| 10/30/2021 | Westminster PA (8-3,8-1) | 42 | at | Bethany WV | 6 | |||
| 11/6/2021 | Bethany WV | 7 | at | Waynesburg (2-8,2-7) | 31 | |||
| 11/13/2021 | Bethany WV | 7 | at | St Vincent (5-6,4-5) | 52 |
| vs Bethany WV | vs Other Opponents | Bethany WV compared to OOs | |
| Record: | 9-1 | 41-53 | |
| Points Scored: | 39.10 | 25.28 | -13.82 |
| Points Allowed: | 10.10 | 28.67 | -18.57 |
| Margin: | 29.00 | -3.39 | -32.39 |
| Total Points: | 49.20 | 53.95 | -4.75 |