| 9/4/2021 | Thiel (0-10) | 14 | at | Allegheny | 42 | TPAC | ||
| 9/11/2021 | Allegheny | 0 | at | Denison (6-4,6-3) | 31 | |||
| 9/18/2021 | Allegheny | 28 | at | Wabash (7-3,6-3) | 36 | |||
| 9/25/2021 | Ohio Wesleyan (8-2,7-2) | 28 | at | Allegheny | 19 | |||
| 10/2/2021 | Kenyon (3-7,3-6) | 27 | at | Allegheny | 13 | |||
| 10/16/2021 | Allegheny | 38 | at | Hiram (1-9,0-9) | 13 | |||
| 10/23/2021 | DePauw (9-3,8-1) | 38 | at | Allegheny | 14 | |||
| 10/30/2021 | Wittenberg (7-3,7-2) | 29 | at | Allegheny | 19 | |||
| 11/6/2021 | Allegheny | 41 | at | Wooster (6-4,5-4) | 59 | |||
| 11/13/2021 | Oberlin (1-9,1-8) | 38 | at | Allegheny | 42 |
| vs Allegheny | vs Other Opponents | Allegheny compared to OOs | |
| Record: | 7-3 | 41-51 | |
| Points Scored: | 31.30 | 26.92 | -4.38 |
| Points Allowed: | 25.60 | 31.66 | -6.06 |
| Margin: | 5.70 | -4.74 | -10.44 |
| Total Points: | 56.90 | 58.58 | -1.68 |