| 9/3/2021 | Bethany WV (1-9) | 21 | at | Hiram | 41 | TPAC | ||
| 9/11/2021 | Wabash (7-3,6-3) | 42 | at | Hiram | 14 | |||
| 9/18/2021 | Hiram | 21 | at | Wittenberg (7-3,7-2) | 51 | |||
| 10/2/2021 | Hiram | 7 | at | DePauw (9-3,8-1) | 57 | |||
| 10/9/2021 | Hiram | 17 | at | Ohio Wesleyan (8-2,7-2) | 34 | |||
| 10/16/2021 | Allegheny (3-7,2-7) | 38 | at | Hiram | 13 | |||
| 10/23/2021 | Oberlin (1-9,1-8) | 31 | at | Hiram | 28 | |||
| 10/30/2021 | Hiram | 14 | at | Wooster (6-4,5-4) | 51 | |||
| 11/6/2021 | Denison (6-4,6-3) | 59 | at | Hiram | 6 | |||
| 11/13/2021 | Hiram | 16 | at | Kenyon (3-7,3-6) | 21 |
| vs Hiram | vs Other Opponents | Hiram compared to OOs | |
| Record: | 9-1 | 42-50 | |
| Points Scored: | 40.50 | 27.01 | -13.49 |
| Points Allowed: | 17.70 | 30.73 | -13.03 |
| Margin: | 22.80 | -3.72 | -26.52 |
| Total Points: | 58.20 | 57.74 | 0.46 |