D3
11 Jan 2022 16:14:08
9/3/2021 | Bethany WV | 21 | at | Hiram | 41 | | | TPAC |
9/4/2021 | Thiel | 14 | at | Allegheny | 42 | | | TPAC |
| Ill. Benedictine | 34 | at | Kenyon | 31 | OT | | NAC |
| Kalamazoo | 24 | at | Oberlin | 17 | | | MIAA |
| Denison | 10 | at | Ohio Northern | 34 | | | @ OAC |
| Ohio Wesleyan | 32 | at | Otterbein | 28 | | | @ OAC |
| Wabash | 33 | at | Rose-Hulman | 23 | | | @ HCA |
| Cortland | 38 | at | Wittenberg | 16 | | | E8 |
| Geneva | 35 | at | Wooster | 42 | | | TPAC |
9/11/2021 | DePauw | 24 | at | Butler | 49 | | | @ Pio (1AA) |
| Allegheny | 0 | at | Denison | 31 | | | |
| Wabash | 42 | at | Hiram | 14 | | | |
| Ohio Wesleyan | 62 | at | Oberlin | 6 | | | |
| Kenyon | 7 | at | Wooster | 49 | | | |
9/18/2021 | Kenyon | 0 | at | DePauw | 44 | | | |
| Denison | 59 | at | Oberlin | 12 | | | |
| Wooster | 7 | at | Ohio Wesleyan | 31 | | | |
| Allegheny | 28 | at | Wabash | 36 | | | |
| Hiram | 21 | at | Wittenberg | 51 | | | |
9/25/2021 | Ohio Wesleyan | 28 | at | Allegheny | 19 | | | |
| Wittenberg | 16 | at | Denison | 21 | | | |
| Oberlin | 21 | at | Kenyon | 24 | | | |
| DePauw | 34 | at | Wooster | 30 | | | |
10/2/2021 | Kenyon | 27 | at | Allegheny | 13 | | | |
| Wabash | 39 | at | Denison | 38 | OT | | |
| Hiram | 7 | at | DePauw | 57 | | | |
| Wooster | 28 | at | Oberlin | 24 | | | |
| Wittenberg | 24 | at | Ohio Wesleyan | 23 | | | |
10/9/2021 | Hiram | 17 | at | Ohio Wesleyan | 34 | | | |
| Oberlin | 20 | at | Wabash | 49 | | | |
| DePauw | 17 | at | Wittenberg | 14 | | | |
10/16/2021 | Ohio Wesleyan | 7 | at | DePauw | 24 | | | |
| Allegheny | 38 | at | Hiram | 13 | | | |
| Denison | 45 | at | Kenyon | 7 | | | |
| Wittenberg | 44 | at | Oberlin | 27 | | | |
| Wooster | 44 | at | Wabash | 41 | | | |
10/23/2021 | DePauw | 38 | at | Allegheny | 14 | | | |
| Wooster | 28 | at | Denison | 52 | | | |
| Oberlin | 31 | at | Hiram | 28 | | | |
| Wabash | 28 | at | Ohio Wesleyan | 35 | OT | | |
| Kenyon | 14 | at | Wittenberg | 38 | | | |
10/30/2021 | Wittenberg | 29 | at | Allegheny | 19 | | | |
| Denison | 10 | at | DePauw | 27 | | | |
| Wabash | 59 | at | Kenyon | 34 | | | |
| Hiram | 14 | at | Wooster | 51 | | | |
11/6/2021 | Oberlin | 13 | at | DePauw | 66 | | | |
| Denison | 59 | at | Hiram | 6 | | | |
| Kenyon | 17 | at | Ohio Wesleyan | 52 | | | |
| Wittenberg | 35 | at | Wabash | 14 | | | |
| Allegheny | 41 | at | Wooster | 59 | | | |
11/13/2021 | Oberlin | 38 | at | Allegheny | 42 | | | |
| Ohio Wesleyan | 35 | at | Denison | 25 | | | |
| Hiram | 16 | at | Kenyon | 21 | | | |
| DePauw | 35 | at | Wabash | 42 | | | |
| Wooster | 29 | at | Wittenberg | 44 | | | |
11/20/2021 | Rose-Hulman | 21 | at | DePauw | 26 | | | HCA |
11/27/2021 | DePauw | 0 | at | Wisconsin-Whitewater | 45 | | | @ WIAC |