| 9/4/2021 | Ohio Wesleyan | 32 | at | Otterbein (1-9) | 28 | at OAC | ||
| 9/11/2021 | Ohio Wesleyan | 62 | at | Oberlin (1-9,1-8) | 6 | |||
| 9/18/2021 | Wooster (6-4,5-4) | 7 | at | Ohio Wesleyan | 31 | |||
| 9/25/2021 | Ohio Wesleyan | 28 | at | Allegheny (3-7,2-7) | 19 | |||
| 10/2/2021 | Wittenberg (7-3,7-2) | 24 | at | Ohio Wesleyan | 23 | |||
| 10/9/2021 | Hiram (1-9,0-9) | 17 | at | Ohio Wesleyan | 34 | |||
| 10/16/2021 | Ohio Wesleyan | 7 | at | DePauw (9-3,8-1) | 24 | |||
| 10/23/2021 | Wabash (7-3,6-3) | 28 | at | Ohio Wesleyan | 35 | OT | ||
| 11/6/2021 | Kenyon (3-7,3-6) | 17 | at | Ohio Wesleyan | 52 | |||
| 11/13/2021 | Ohio Wesleyan | 35 | at | Denison (6-4,6-3) | 25 |
| vs Ohio Wesleyan | vs Other Opponents | Ohio Wesleyan compared to OOs | |
| Record: | 2-8 | 42-50 | |
| Points Scored: | 19.50 | 28.32 | 8.82 |
| Points Allowed: | 33.90 | 31.72 | 2.18 |
| Margin: | -14.40 | -3.40 | 11.00 |
| Total Points: | 53.40 | 60.04 | -6.64 |