| 9/3/2021 | Anderson | 7 | at | Hope (8-2) | 42 | at MIAA | ||
| 9/11/2021 | Lakeland (8-2) | 54 | at | Anderson | 41 | NAC | ||
| 9/18/2021 | Anderson | 2 | at | Alma (5-5) | 51 | at MIAA | ||
| 10/2/2021 | Anderson | 0 | at | Hanover (5-5,4-3) | 49 | |||
| 10/9/2021 | Bluffton (4-6,3-4) | 32 | at | Anderson | 20 | |||
| 10/16/2021 | Anderson | 7 | at | Rose-Hulman (8-3,7-0) | 62 | |||
| 10/23/2021 | Franklin (6-4,4-3) | 17 | at | Anderson | 0 | |||
| 10/30/2021 | Anderson | 18 | at | Mt St Joseph (6-4,5-2) | 35 | |||
| 11/6/2021 | Defiance (1-9,1-6) | 14 | at | Anderson | 42 | |||
| 11/13/2021 | Anderson | 0 | at | Manchester (3-7,3-4) | 3 |
| vs Anderson | vs Other Opponents | Anderson compared to OOs | |
| Record: | 9-1 | 45-46 | |
| Points Scored: | 35.90 | 25.74 | -10.16 |
| Points Allowed: | 13.70 | 25.40 | -11.70 |
| Margin: | 22.20 | 0.34 | -21.86 |
| Total Points: | 49.60 | 51.14 | -1.54 |