| 9/4/2021 | Coast Guard | 16 | at | University of New England (4-5) | 0 | at CCF | ||
| 9/11/2021 | Coast Guard | 18 | at | Curry (3-6) | 21 | at CCF | ||
| 9/18/2021 | Nichols (2-8) | 6 | at | Coast Guard | 33 | CCF | ||
| 9/25/2021 | Anna Maria (7-3) | 29 | at | Coast Guard | 24 | ECFC | ||
| 10/2/2021 | Norwich (2-8,1-5) | 24 | at | Coast Guard | 21 | |||
| 10/9/2021 | Coast Guard | 0 | at | Springfield (7-4,6-0) | 60 | |||
| 10/16/2021 | Coast Guard | 7 | at | Catholic (6-4,4-2) | 30 | |||
| 10/30/2021 | MIT (5-4,3-3) | 21 | at | Coast Guard | 7 | |||
| 11/6/2021 | Coast Guard | 6 | at | Worcester Polytechnic (3-7,2-4) | 38 | |||
| 11/13/2021 | Merchant Marine (9-1,5-1) | 49 | at | Coast Guard | 14 |
| vs Coast Guard | vs Other Opponents | Coast Guard compared to OOs | |
| Record: | 8-2 | 40-48 | |
| Points Scored: | 27.80 | 25.19 | -2.61 |
| Points Allowed: | 14.60 | 27.01 | -12.41 |
| Margin: | 13.20 | -1.82 | -15.02 |
| Total Points: | 42.40 | 52.20 | -9.80 |