| 9/2/2021 | Pittsburg State | 35 | at | Central Missouri (4-7,3-7) | 16 | | | |
| 9/11/2021 | Nebraska-Kearney (10-3,8-2) | 28 | at | Pittsburg State | 17 | | | |
| 9/18/2021 | Pittsburg State | 48 | at | Northeastern State (2-9,1-9) | 13 | | | |
| 9/25/2021 | Emporia State (6-6,5-5) | 28 | at | Pittsburg State | 30 | | | |
| 10/2/2021 | Pittsburg State | 20 | at | Missouri Southern (3-8,2-8) | 16 | | | |
| 10/9/2021 | Pittsburg State | 19 | at | Northwest Missouri State (11-2,9-1) | 20 | | | |
| 10/16/2021 | Lincoln MO (0-10) | 7 | at | Pittsburg State | 59 | | | GLV |
| 10/23/2021 | Pittsburg State | 34 | at | Missouri Western (6-5,5-5) | 14 | | | |
| 10/30/2021 | Central Oklahoma (4-7,3-7) | 20 | at | Pittsburg State | 26 | | | |
| 11/6/2021 | Washburn (9-3,8-2) | 28 | at | Pittsburg State | 26 | | | |
| 11/13/2021 | Pittsburg State | 34 | at | Fort Hays State (5-6,4-6) | 24 | | | |