| 9/2/2021 | Washburn (9-3) | 76 | at | Lincoln MO | 12 | MAIAA | ||
| 9/9/2021 | Lincoln MO | at | Northwest Missouri State (11-2) | Cancelled | at MAIAA | |||
| 9/18/2021 | Lincoln MO | 0 | at | Fort Hays State (5-6) | 72 | at MAIAA | ||
| 9/25/2021 | Northeastern State (2-9) | 49 | at | Lincoln MO | 48 | MAIAA | ||
| 10/2/2021 | Lincoln MO | 28 | at | Central Oklahoma (4-7) | 69 | at MAIAA | ||
| 10/9/2021 | Missouri Southern (3-8) | 52 | at | Lincoln MO | 32 | MAIAA | ||
| 10/16/2021 | Lincoln MO | 7 | at | Pittsburg State (8-3) | 59 | at MAIAA | ||
| 10/23/2021 | Lincoln MO | 0 | at | Nebraska-Kearney (10-3) | 56 | at MAIAA | ||
| 10/30/2021 | Central Missouri (4-7) | 77 | at | Lincoln MO | 35 | MAIAA | ||
| 11/6/2021 | Lincoln MO | 21 | at | Emporia State (6-6) | 56 | at MAIAA | ||
| 11/13/2021 | Missouri Western (6-5) | 41 | at | Lincoln MO | 12 | MAIAA |
| vs Lincoln MO | vs Other Opponents | Lincoln MO compared to OOs | |
| Record: | 10-0 | 58-59 | |
| Points Scored: | 60.70 | 26.87 | -33.83 |
| Points Allowed: | 19.50 | 26.85 | -7.35 |
| Margin: | 41.20 | 0.02 | -41.18 |
| Total Points: | 80.20 | 53.72 | 26.48 |