| 9/4/2021 | Emporia State (6-6,5-5) | 38 | at | Northeastern State | 7 | | | |
| 9/11/2021 | Northeastern State | 21 | at | Missouri Southern (3-8,2-8) | 17 | | | |
| 9/18/2021 | Pittsburg State (8-3,7-3) | 48 | at | Northeastern State | 13 | | | |
| 9/25/2021 | Northeastern State | 49 | at | Lincoln MO (0-10) | 48 | | | at GLV |
| 10/2/2021 | Central Missouri (4-7,3-7) | 41 | at | Northeastern State | 10 | | | |
| 10/7/2021 | Central Oklahoma (4-7,3-7) | 49 | at | Northeastern State | 9 | | | |
| 10/16/2021 | Northeastern State | 24 | at | Missouri Western (6-5,5-5) | 57 | | | |
| 10/23/2021 | Northwest Missouri State (11-2,9-1) | 59 | at | Northeastern State | 7 | | | |
| 10/30/2021 | Northeastern State | 0 | at | Washburn (9-3,8-2) | 35 | | | |
| 11/6/2021 | Fort Hays State (5-6,4-6) | 64 | at | Northeastern State | 6 | | | |
| 11/13/2021 | Northeastern State | 10 | at | Nebraska-Kearney (10-3,8-2) | 56 | | | |