| 9/2/2021 | Washburn | 76 | at | Lincoln MO (0-10) | 12 | | | at GLV |
| 9/9/2021 | Central Missouri (4-7,3-7) | 10 | at | Washburn | 29 | | | |
| 9/18/2021 | Washburn | 24 | at | Nebraska-Kearney (10-3,8-2) | 28 | | | |
| 9/25/2021 | Missouri Western (6-5,5-5) | 41 | at | Washburn | 47 | | | |
| 10/2/2021 | Washburn | 30 | at | Emporia State (6-6,5-5) | 35 | | | |
| 10/9/2021 | Fort Hays State (5-6,4-6) | 20 | at | Washburn | 23 | | | |
| 10/16/2021 | Northwest Missouri State (11-2,9-1) | 16 | at | Washburn | 17 | | | |
| 10/23/2021 | Washburn | 29 | at | Central Oklahoma (4-7,3-7) | 17 | | | |
| 10/30/2021 | Northeastern State (2-9,1-9) | 0 | at | Washburn | 35 | | | |
| 11/6/2021 | Washburn | 28 | at | Pittsburg State (8-3,7-3) | 26 | | | |
| 11/13/2021 | Missouri Southern (3-8,2-8) | 28 | at | Washburn | 38 | | | |
| 11/20/2021 | Washburn | 14 | at | Harding (11-2) | 30 | | | at GAC |