| 9/2/2021 | Northwest Missouri State | 15 | at | Fort Hays State (5-6,4-6) | 7 | | | |
| 9/9/2021 | Lincoln MO (0-10) | | at | Northwest Missouri State | | | Cancelled | GLV |
| 9/18/2021 | Northwest Missouri State | 47 | at | Central Missouri (4-7,3-7) | 7 | | | |
| 9/25/2021 | Central Oklahoma (4-7,3-7) | 0 | at | Northwest Missouri State | 38 | | | |
| 10/2/2021 | Northwest Missouri State | 30 | at | Missouri Western (6-5,5-5) | 7 | | | |
| 10/9/2021 | Pittsburg State (8-3,7-3) | 19 | at | Northwest Missouri State | 20 | | | |
| 10/16/2021 | Northwest Missouri State | 16 | at | Washburn (9-3,8-2) | 17 | | | |
| 10/23/2021 | Northwest Missouri State | 59 | at | Northeastern State (2-9,1-9) | 7 | | | |
| 10/30/2021 | Nebraska-Kearney (10-3,8-2) | 13 | at | Northwest Missouri State | 66 | | | |
| 11/6/2021 | Northwest Missouri State | 49 | at | Missouri Southern (3-8,2-8) | 7 | | | |
| 11/13/2021 | Emporia State (6-6,5-5) | 7 | at | Northwest Missouri State | 35 | | | |
| 11/20/2021 | Central Washington (8-3) | 21 | at | Northwest Missouri State | 50 | | | GNWAC |
| 11/27/2021 | Northwest Missouri State | 28 | at | Harding (11-2) | 9 | | | at GAC |
| 12/4/2021 | Northwest Missouri State | 20 | at | Ferris State (14-0) | 41 | | | at GLIAC |