| 9/3/2021 | Michigan State (11-2,7-2) | 38 | at | Northwestern | 21 | |||
| 9/11/2021 | Indiana State (5-6) | 6 | at | Northwestern | 24 | MVC (1AA) | ||
| 9/18/2021 | Northwestern | 23 | at | Duke (3-9) | 30 | at ACC | ||
| 9/25/2021 | Ohio (3-9) | 6 | at | Northwestern | 35 | MAC | ||
| 10/2/2021 | Northwestern | 7 | at | Nebraska (3-9,1-8) | 56 | |||
| 10/16/2021 | Rutgers (5-8,2-7) | 7 | at | Northwestern | 21 | |||
| 10/23/2021 | Northwestern | 7 | at | Michigan (12-2,9-1) | 33 | |||
| 10/30/2021 | Minnesota (9-4,6-3) | 41 | at | Northwestern | 14 | |||
| 11/6/2021 | Iowa (10-4,7-3) | 17 | at | Northwestern | 12 | |||
| 11/13/2021 | Northwestern | 7 | at | Wisconsin (9-4,6-3) | 35 | |||
| 11/20/2021 | Purdue (9-4,6-3) | 32 | at | Northwestern | 14 | |||
| 11/27/2021 | Northwestern | 14 | at | Illinois (5-7,4-5) | 47 |
| vs Northwestern | vs Other Opponents | Northwestern compared to OOs | |
| Record: | 9-3 | 75-65 | |
| Points Scored: | 29.00 | 24.91 | -4.09 |
| Points Allowed: | 16.58 | 24.34 | -7.76 |
| Margin: | 12.42 | 0.57 | -11.85 |
| Total Points: | 45.58 | 49.25 | -3.67 |