| 9/2/2021 | Albany State GA (10-2) | 24 | at | Mississippi College | 0 | SIAC | ||
| 9/18/2021 | Fort Lauderdale (0-7) | 0 | at | Mississippi College | 63 | None (Unk?) | ||
| 9/25/2021 | West Alabama (7-4,4-4) | 31 | at | Mississippi College | 28 | |||
| 10/2/2021 | Mississippi College | 42 | at | North Greenville (5-6,2-5) | 21 | |||
| 10/9/2021 | West Georgia (9-3,6-3) | 40 | at | Mississippi College | 21 | |||
| 10/16/2021 | Mississippi College | 20 | at | Shorter (3-8,0-7) | 7 | |||
| 10/23/2021 | Valdosta State (12-2,7-1) | 41 | at | Mississippi College | 14 | |||
| 10/30/2021 | West Florida (9-2,6-1) | 63 | at | Mississippi College | 28 | |||
| 11/6/2021 | Mississippi College | 21 | at | Delta State (5-6,3-5) | 24 | OT | ||
| 11/13/2021 | Mississippi College | 28 | at | West Alabama (7-4,4-4) | 24 |
| vs Mississippi College | vs Other Opponents | Mississippi College compared to OOs | |
| Record: | 6-4 | 60-39 | |
| Points Scored: | 27.50 | 31.88 | 4.38 |
| Points Allowed: | 26.50 | 25.12 | 1.38 |
| Margin: | 1.00 | 6.76 | 5.76 |
| Total Points: | 54.00 | 57.00 | -3.00 |