| 9/11/2021 | Allen (3-5) | 20 | at | Johnson C Smith | 19 | SIAC | ||
| 9/18/2021 | Bluefield St WV (3-3) | 20 | at | Johnson C Smith | 12 | D2Ind | ||
| 9/25/2021 | Virginia Union (6-4,5-2) | 43 | at | Johnson C Smith | 7 | |||
| 10/2/2021 | Johnson C Smith | 7 | at | Bowie State (12-2,8-0) | 44 | |||
| 10/9/2021 | Winston-Salem State (3-6,3-4) | 26 | at | Johnson C Smith | 12 | |||
| 10/16/2021 | Johnson C Smith | 12 | at | Fayetteville State (8-2,8-1) | 55 | |||
| 10/23/2021 | Johnson C Smith | 14 | at | Shaw (6-4,5-2) | 20 | |||
| 10/30/2021 | St Augustine's (1-7,1-6) | 13 | at | Johnson C Smith | 34 | |||
| 11/6/2021 | Livingstone (1-8,1-5) | at | Johnson C Smith | Cancelled at 17-3 |
| vs Johnson C Smith | vs Other Opponents | Johnson C Smith compared to OOs | |
| Record: | 7-1 | 36-40 | |
| Points Scored: | 30.13 | 22.49 | -7.64 |
| Points Allowed: | 14.63 | 23.51 | -8.88 |
| Margin: | 15.50 | -1.02 | -16.52 |
| Total Points: | 44.76 | 46.00 | -1.24 |