| 9/4/2021 | Brevard (6-4) | 14 | at | Shorter | 38 | USASC (D3) | ||
| 9/11/2021 | Shorter | 12 | at | Albany State GA (10-2) | 28 | at SIAC | ||
| 9/18/2021 | Shorter | 38 | at | Clark Atlanta (2-8) | 17 | at SIAC | ||
| 9/25/2021 | West Georgia (9-3,6-3) | 56 | at | Shorter | 0 | |||
| 10/2/2021 | Shorter | 13 | at | Valdosta State (12-2,7-1) | 49 | |||
| 10/9/2021 | West Alabama (7-4,4-4) | 44 | at | Shorter | 7 | |||
| 10/16/2021 | Mississippi College (4-6,3-5) | 20 | at | Shorter | 7 | |||
| 10/23/2021 | Shorter | 23 | at | West Florida (9-2,6-1) | 45 | |||
| 10/30/2021 | Shorter | 13 | at | Delta State (5-6,3-5) | 14 | |||
| 11/6/2021 | Erskine (3-8) | 7 | at | Shorter | 38 | D2Ind | ||
| 11/13/2021 | Shorter | 0 | at | North Greenville (5-6,2-5) | 56 |
| vs Shorter | vs Other Opponents | Shorter compared to OOs | |
| Record: | 8-3 | 64-48 | |
| Points Scored: | 31.82 | 29.91 | -1.91 |
| Points Allowed: | 17.18 | 24.39 | -7.21 |
| Margin: | 14.64 | 5.52 | -9.12 |
| Total Points: | 49.00 | 54.30 | -5.30 |