| 9/12/2020 | Duke (2-9,1-9) | 13 | at | Notre Dame | 27 | |||
| 9/19/2020 | South Florida (1-8) | 0 | at | Notre Dame | 52 | AAC | ||
| 10/10/2020 | Florida State (3-6,2-6) | 26 | at | Notre Dame | 42 | |||
| 10/17/2020 | Louisville (4-7,3-7) | 7 | at | Notre Dame | 12 | |||
| 10/24/2020 | Notre Dame | 45 | at | Pittsburgh (6-5,5-5) | 3 | |||
| 10/31/2020 | Notre Dame | 31 | at | Georgia Tech (3-7,3-6) | 13 | |||
| 11/7/2020 | Clemson (10-2,9-1) | 40 | at | Notre Dame | 47 | 2OT | ||
| 11/14/2020 | Notre Dame | 45 | at | Boston College (6-5,5-5) | 31 | |||
| 11/27/2020 | Notre Dame | 31 | at | North Carolina (8-4,7-3) | 17 | |||
| 12/5/2020 | Syracuse (1-10,1-9) | 21 | at | Notre Dame | 45 | |||
| 12/19/2020 | Clemson (10-2,9-1) | 34 | vs | Notre Dame | 10 | ACC Championship | ||
| 1/1/2021 | Notre Dame | 14 | vs | Alabama (13-0) | 31 | Rose Bowl | vs SEC |
| vs Notre Dame | vs Other Opponents | Notre Dame compared to OOs | |
| Record: | 2-10 | 64-54 | |
| Points Scored: | 19.67 | 34.20 | 14.53 |
| Points Allowed: | 33.42 | 28.75 | 4.67 |
| Margin: | -13.75 | 5.45 | 19.20 |
| Total Points: | 53.09 | 62.95 | -9.86 |