| 9/12/2020 | The Citadel (0-4) | 6 | at | South Florida | 27 | SoCon (1AA) | ||
| 9/19/2020 | South Florida | 0 | at | Notre Dame (10-2) | 52 | at ACC | ||
| 10/3/2020 | South Florida | 7 | at | Cincinnati (9-1,7-0) | 28 | |||
| 10/10/2020 | East Carolina (3-6,3-5) | 44 | at | South Florida | 24 | |||
| 10/17/2020 | South Florida | 37 | at | Temple (1-6,1-6) | 39 | |||
| 10/23/2020 | Tulsa (6-3,6-1) | 42 | at | South Florida | 13 | |||
| 11/7/2020 | South Florida | 33 | at | Memphis (8-3,5-3) | 34 | |||
| 11/14/2020 | South Florida | 21 | at | Houston (3-5,3-3) | 56 | |||
| 11/21/2020 | Navy (3-7,3-4) | at | South Florida | PPD | ||||
| 11/27/2020 | UCF (6-4,5-3) | 58 | at | South Florida | 46 |
| vs South Florida | vs Other Opponents | South Florida compared to OOs | |
| Record: | 8-1 | 41-40 | |
| Points Scored: | 39.89 | 28.27 | -11.62 |
| Points Allowed: | 23.11 | 28.57 | -5.46 |
| Margin: | 16.78 | -0.30 | -17.08 |
| Total Points: | 63.00 | 56.84 | 6.16 |