Big5
11 Jan 2021 21:53:04
| 9/10/2020 | UAB | 14 | at | Miami-Florida | 31 | | | CUSA |
| 9/12/2020 | Georgia Tech | 16 | at | Florida State | 13 | | | |
| Western Kentucky | 21 | at | Louisville | 35 | | | CUSA |
| Syracuse | 6 | at | North Carolina | 31 | | | |
| Duke | 13 | at | Notre Dame | 27 | | | |
| Austin Peay | 0 | at | Pittsburgh | 55 | | | OVC (1AA) |
| Clemson | 37 | at | Wake Forest | 13 | | | |
| 9/19/2020 | The Citadel | 0 | at | Clemson | 49 | | | SoCon (1AA) |
| Boston College | 26 | at | Duke | 6 | | | |
| UCF | 49 | at | Georgia Tech | 21 | | | AAC |
| Miami-Florida | 47 | at | Louisville | 34 | | | |
| Wake Forest | 42 | at | North Carolina State | 45 | | | |
| South Florida | 0 | at | Notre Dame | 52 | | | AAC |
| Syracuse | 10 | at | Pittsburgh | 21 | | | |
| 9/26/2020 | Texas State | 21 | at | Boston College | 24 | | | SBC |
| Florida State | 10 | at | Miami-Florida | 52 | | | |
| Louisville | 20 | at | Pittsburgh | 23 | | | |
| Georgia Tech | 20 | at | Syracuse | 37 | | | |
| Duke | 20 | at | Virginia | 38 | | | |
| North Carolina State | 24 | at | Virginia Tech | 45 | | | |
| 10/2/2020 | Campbell | 14 | at | Wake Forest | 66 | | | BigS (1AA) |
| 10/3/2020 | North Carolina | 26 | at | Boston College | 22 | | | |
| Virginia | 23 | at | Clemson | 41 | | | |
| Virginia Tech | 38 | at | Duke | 31 | | | |
| Jacksonville State | 24 | at | Florida State | 41 | | | OVC (1AA) |
| North Carolina State | 30 | at | Pittsburgh | 29 | | | |
| 10/9/2020 | Louisville | 27 | at | Georgia Tech | 46 | | | |
| 10/10/2020 | Pittsburgh | 30 | at | Boston College | 31 | | | |
| Miami-Florida | 17 | at | Clemson | 42 | | | |
| Virginia Tech | 45 | at | North Carolina | 56 | | | |
| Florida State | 26 | at | Notre Dame | 42 | | | |
| Duke | 38 | at | Syracuse | 24 | | | |
| North Carolina State | 38 | at | Virginia | 21 | | | |
| 10/17/2020 | North Carolina | 28 | at | Florida State | 31 | | | |
| Clemson | 73 | at | Georgia Tech | 7 | | | |
| Pittsburgh | 19 | at | Miami-Florida | 31 | | | |
| Duke | 20 | at | North Carolina State | 31 | | | |
| Louisville | 7 | at | Notre Dame | 12 | | | |
| Liberty | 38 | at | Syracuse | 21 | | | Ind |
| Boston College | 14 | at | Virginia Tech | 40 | | | |
| Virginia | 23 | at | Wake Forest | 40 | | | |
| 10/24/2020 | Georgia Tech | 27 | at | Boston College | 48 | | | |
| Syracuse | 21 | at | Clemson | 47 | | | |
| Florida State | 16 | at | Louisville | 48 | | | |
| Virginia | 14 | at | Miami-Florida | 19 | | | |
| North Carolina State | 21 | at | North Carolina | 48 | | | |
| Notre Dame | 45 | at | Pittsburgh | 3 | | | |
| Virginia Tech | 16 | at | Wake Forest | 23 | | | |
| 10/31/2020 | Boston College | 28 | at | Clemson | 34 | | | |
| UNC-Charlotte | 19 | at | Duke | 53 | | | CUSA |
| Notre Dame | 31 | at | Georgia Tech | 13 | | | |
| Virginia Tech | 42 | at | Louisville | 35 | | | |
| Wake Forest | 38 | at | Syracuse | 14 | | | |
| North Carolina | 41 | at | Virginia | 44 | | | |
| 11/6/2020 | Miami-Florida | 44 | at | North Carolina State | 41 | | | |
| 11/7/2020 | North Carolina | 56 | at | Duke | 24 | | | |
| Pittsburgh | 41 | at | Florida State | 17 | | | |
| Clemson | 40 | at | Notre Dame | 47 | 2OT | | |
| Boston College | 16 | at | Syracuse | 13 | | | |
| Louisville | | at | Virginia | | | PPD | |
| Liberty | 38 | at | Virginia Tech | 35 | | | Ind |
| 11/14/2020 | Notre Dame | 45 | at | Boston College | 31 | | | |
| Pittsburgh | | at | Georgia Tech | | | PPD | |
| Florida State | 22 | at | North Carolina State | 38 | | | |
| Wake Forest | 53 | at | North Carolina | 59 | | | |
| Louisville | 17 | aT | Virginia | 31 | | | |
| Miami-Florida | 25 | at | Virginia Tech | 24 | | | |
| 11/20/2020 | Syracuse | 0 | at | Louisville | 30 | | | |
| 11/21/2020 | Wake Forest | | at | Duke | | | CCD | |
| Clemson | | at | Florida State | | | PPD | |
| Georgia Tech | | at | Miami-Florida | | | PPD | |
| Liberty | 14 | at | North Carolina State | 15 | | | Ind |
| Virginia Tech | 14 | at | Pittsburgh | 47 | | | |
| Abilene Christian | 15 | at | Virginia | 55 | | | SLC (1AA) |
| 11/27/2020 | Notre Dame | 31 | at | North Carolina | 17 | | | |
| 11/28/2020 | Louisville | 27 | at | Boston College | 34 | | | |
| Pittsburgh | 17 | at | Clemson | 52 | | | |
| Virginia | | at | Florida State | | | PPD | |
| Duke | 33 | at | Georgia Tech | 56 | | | |
| North Carolina State | 36 | at | Syracuse | 29 | | | |
| 12/5/2020 | Miami-Florida | 48 | at | Duke | 0 | | | |
| Georgia Tech | 13 | at | North Carolina State | 23 | | | |
| Western Carolina | 9 | at | North Carolina | 49 | | | SoCon (1AA) |
| Syracuse | 21 | at | Notre Dame | 45 | | | |
| Boston College | 32 | at | Virginia | 43 | | | |
| Clemson | 45 | at | Virginia Tech | 10 | | | |
| 12/10/2020 | Pittsburgh | 34 | at | Georgia Tech | 20 | | | |
| 12/12/2020 | Duke | 35 | at | Florida State | 56 | | | |
| Wake Forest | 21 | at | Louisville | 45 | | | |
| North Carolina | 62 | at | Miami-Florida | 26 | | | |
| Virginia | 15 | at | Virginia Tech | 33 | | | |
| 12/19/2020 | Georgia Tech | | at | Miami-Florida | | | CCD | |
| Clemson | 34 | vs | Notre Dame | 10 | | ACC Championship | |
| Florida State | | at | Wake Forest | | | CCD | |
| 12/29/2020 | Oklahoma State | 37 | vs | Miami-Florida | 34 | | Cheez-It Bowl | vs B12 |
| 12/30/2020 | Wake Forest | 28 | vs | Wisconsin | 42 | | Duke's Mayo Bowl | vs B10 |
| 1/1/2021 | Notre Dame | 14 | vs | Alabama | 31 | | Rose Bowl | vs SEC |
| Ohio State | 49 | vs | Clemson | 28 | | Sugar Bowl | vs B10 |
| 1/2/2021 | North Carolina State | 21 | vs | Kentucky | 23 | | Gator Bowl | vs SEC |
| Texas A&M | 41 | vs | North Carolina | 27 | | Orange Bowl | vs SEC |