| 9/12/2020 | Austin Peay (0-3) | 0 | at | Pittsburgh | 55 | OVC (1AA) | ||
| 9/19/2020 | Syracuse (1-10,1-9) | 10 | at | Pittsburgh | 21 | |||
| 9/26/2020 | Louisville (4-7,3-7) | 20 | at | Pittsburgh | 23 | |||
| 10/3/2020 | North Carolina State (8-4,7-3) | 30 | at | Pittsburgh | 29 | |||
| 10/10/2020 | Pittsburgh | 30 | at | Boston College (6-5,5-5) | 31 | |||
| 10/17/2020 | Pittsburgh | 19 | at | Miami-Florida (8-3,7-2) | 31 | |||
| 10/24/2020 | Notre Dame (10-2,9-1) | 45 | at | Pittsburgh | 3 | |||
| 11/7/2020 | Pittsburgh | 41 | at | Florida State (3-6,2-6) | 17 | |||
| 11/14/2020 | Pittsburgh | at | Georgia Tech (3-7,3-6) | PPD | ||||
| 11/21/2020 | Virginia Tech (5-6,5-5) | 14 | at | Pittsburgh | 47 | |||
| 11/28/2020 | Pittsburgh | 17 | at | Clemson (10-2,9-1) | 52 | |||
| 12/10/2020 | Pittsburgh | 34 | at | Georgia Tech (3-7,3-6) | 20 |
| vs Pittsburgh | vs Other Opponents | Pittsburgh compared to OOs | |
| Record: | 5-6 | 56-55 | |
| Points Scored: | 24.55 | 29.78 | 5.23 |
| Points Allowed: | 29.00 | 29.89 | -0.89 |
| Margin: | -4.45 | -0.11 | 4.34 |
| Total Points: | 53.55 | 59.67 | -6.12 |