| 9/1/2018 | Louisiana Tech | 30 | at | South Alabama (3-9) | 26 | at SBC | ||
| 9/8/2018 | Southern (7-4) | 17 | at | Louisiana Tech | 54 | SWAC (1AA) | ||
| 9/22/2018 | Louisiana Tech | 21 | at | LSU (10-3) | 38 | at SEC | ||
| 9/29/2018 | Louisiana Tech | 29 | at | North Texas (9-4,5-3) | 27 | |||
| 10/6/2018 | UAB (11-3,8-1) | 28 | at | Louisiana Tech | 7 | |||
| 10/13/2018 | Louisiana Tech | 31 | at | Texas-San Antonio (3-9,2-6) | 3 | |||
| 10/20/2018 | UTEP (1-11,1-7) | 24 | at | Louisiana Tech | 31 | |||
| 10/26/2018 | Louisiana Tech | 21 | at | Florida Atlantic (5-7,3-5) | 13 | |||
| 11/3/2018 | Louisiana Tech | 3 | at | Mississippi State (8-5) | 45 | at SEC | ||
| 11/10/2018 | Rice (2-11,1-7) | 13 | at | Louisiana Tech | 28 | |||
| 11/17/2018 | Louisiana Tech | 20 | at | Southern Miss (6-5,5-3) | 21 | |||
| 11/24/2018 | Western Kentucky (3-9,2-6) | 30 | at | Louisiana Tech | 15 | |||
| 12/22/2018 | Hawaii (8-6) | 14 | vs | Louisiana Tech | 31 | Hawai'i Bowl | MW |
| vs Louisiana Tech | vs Other Opponents | Louisiana Tech compared to OOs | |
| Record: | 5-8 | 71-78 | |
| Points Scored: | 23.00 | 26.41 | 3.41 |
| Points Allowed: | 24.69 | 27.42 | -2.73 |
| Margin: | -1.69 | -1.01 | 0.68 |
| Total Points: | 47.69 | 53.83 | -6.14 |