| 8/25/2018 | North Carolina A&T (10-2) | 20 | vs | Jacksonville State | 17 | Montgomery AL | MEAC | |
| 9/8/2018 | Mississippi Valley State (1-10) | 0 | at | Jacksonville State | 71 | SWAC | ||
| 9/22/2018 | Tennessee Tech (1-10,1-7) | 20 | at | Jacksonville State | 48 | |||
| 9/29/2018 | Austin Peay (5-6,3-5) | 32 | at | Jacksonville State | 48 | |||
| 10/6/2018 | Jacksonville State | 56 | at | Eastern Kentucky (7-4,5-2) | 7 | |||
| 10/13/2018 | Eastern Illinois (3-8,3-5) | 22 | at | Jacksonville State | 49 | |||
| 10/20/2018 | Jacksonville State | 14 | at | SE Missouri State (9-4,6-2) | 37 | |||
| 10/27/2018 | Jacksonville State | 42 | at | Murray State (5-6,5-3) | 15 | |||
| 11/3/2018 | Tennessee-Martin (2-9,2-6) | 14 | at | Jacksonville State | 21 | |||
| 11/10/2018 | Jacksonville State | 41 | at | Tennessee State (4-5,3-4) | 14 | |||
| 11/17/2018 | Jacksonville State | 52 | vs | Kennesaw St (11-2) | 60 | 5OT | Atlanta GA | vs BigS |
| 11/24/2018 | East Tennessee St (8-4) | 27 | at | Jacksonville State | 34 | SoCon | ||
| 12/1/2018 | Jacksonville State | 27 | at | Maine (10-4) | 55 | 1AA Playoff Round 2 | at CAAF |
| vs Jacksonville State | vs Other Opponents | Jacksonville State compared to OOs | |
| Record: | 4-9 | 72-65 | |
| Points Scored: | 24.85 | 29.69 | 4.84 |
| Points Allowed: | 40.00 | 29.34 | 10.66 |
| Margin: | -15.15 | 0.35 | 15.50 |
| Total Points: | 64.85 | 59.03 | 5.82 |