| 9/1/2018 | SE Missouri State | 21 | at | Arkansas State (8-5) | 48 | at SBC | ||
| 9/8/2018 | Dayton (6-5) | 21 | at | SE Missouri State | 40 | Pio | ||
| 9/15/2018 | SE Missouri State | 48 | at | Southern Illinois (2-9) | 44 | at MVC | ||
| 9/22/2018 | SE Missouri State | 14 | at | Eastern Kentucky (7-4,5-2) | 23 | |||
| 10/6/2018 | SE Missouri State | 70 | at | Tennessee Tech (1-10,1-7) | 38 | |||
| 10/13/2018 | Austin Peay (5-6,3-5) | 27 | at | SE Missouri State | 31 | |||
| 10/20/2018 | Jacksonville State (9-4,7-1) | 14 | at | SE Missouri State | 37 | |||
| 10/27/2018 | SE Missouri State | 56 | at | Tennessee-Martin (2-9,2-6) | 33 | |||
| 11/3/2018 | Tennessee State (4-5,3-4) | 21 | at | SE Missouri State | 38 | |||
| 11/10/2018 | SE Missouri State | 38 | at | Murray State (5-6,5-3) | 40 | |||
| 11/17/2018 | Eastern Illinois (3-8,3-5) | 32 | at | SE Missouri State | 38 | |||
| 11/24/2018 | Stony Brook (7-5) | 14 | at | SE Missouri State | 28 | CAAF | ||
| 12/1/2018 | SE Missouri State | 23 | at | Weber State (10-3) | 48 | 1AA Playoff Round 2 | at BSky |
| vs SE Missouri State | vs Other Opponents | SE Missouri State compared to OOs | |
| Record: | 4-9 | 65-70 | |
| Points Scored: | 31.00 | 29.63 | -1.37 |
| Points Allowed: | 37.08 | 30.25 | 6.83 |
| Margin: | -6.08 | -0.62 | 5.46 |
| Total Points: | 68.08 | 59.88 | 8.20 |