| 9/1/2018 | Bethune-Cookman (7-5) | 3 | at | Tennessee State | 34 | MEAC | ||
| 9/8/2018 | Jackson State (5-5) | vs | Tennessee State | CCD Memphis TN | SWAC | |||
| 9/15/2018 | Tennessee State | vs | Hampton (7-3) | CCD | vs Ind1AA | |||
| 9/22/2018 | Tennessee State | 41 | at | Eastern Illinois (3-8,3-5) | 40 | |||
| 9/29/2018 | Tennessee State | 27 | at | Vanderbilt (6-7) | 31 | at SEC | ||
| 10/6/2018 | Tennessee State | 34 | at | Austin Peay (5-6,3-5) | 49 | |||
| 10/13/2018 | Tennessee State | 21 | at | Murray State (5-6,5-3) | 45 | |||
| 10/20/2018 | Tennessee Tech (1-10,1-7) | 14 | at | Tennessee State | 41 | |||
| 11/3/2018 | Tennessee State | 21 | at | SE Missouri State (9-4,6-2) | 38 | |||
| 11/10/2018 | Jacksonville State (9-4,7-1) | 41 | at | Tennessee State | 14 | |||
| 11/17/2018 | Tennessee-Martin (2-9,2-6) | 28 | at | Tennessee State | 31 | OT |
| vs Tennessee State | vs Other Opponents | Tennessee State compared to OOs | |
| Record: | 5-4 | 54-63 | |
| Points Scored: | 32.11 | 29.68 | -2.43 |
| Points Allowed: | 29.33 | 32.07 | -2.74 |
| Margin: | 2.78 | -2.39 | -5.17 |
| Total Points: | 61.44 | 61.75 | -0.31 |