| 9/1/2018 | Mars Hill (4-6) | 7 | at | East Tennessee St | 28 | SAC (D2) | ||
| 9/8/2018 | East Tennessee St | 3 | at | Tennessee (5-7) | 59 | at SEC | ||
| 9/14/2018 | East Tennessee St | 27 | at | VMI (1-10,0-8) | 24 | |||
| 9/22/2018 | Furman (6-4,6-2) | 27 | at | East Tennessee St | 29 | |||
| 9/29/2018 | Chattanooga (6-5,4-4) | 14 | at | East Tennessee St | 17 | |||
| 10/6/2018 | Gardner-Webb (3-8) | 0 | at | East Tennessee St | 45 | BigS | ||
| 10/13/2018 | East Tennessee St | 26 | at | The Citadel (5-6,4-4) | 23 | |||
| 10/20/2018 | East Tennessee St | 17 | at | Wofford (9-4,6-2) | 30 | |||
| 10/27/2018 | Western Carolina (3-8,1-7) | 43 | at | East Tennessee St | 45 | 3OT | ||
| 11/3/2018 | East Tennessee St | 21 | at | Mercer (5-6,4-4) | 18 | |||
| 11/17/2018 | Samford (6-5,5-3) | 38 | at | East Tennessee St | 27 | |||
| 11/24/2018 | East Tennessee St | 27 | at | Jacksonville State (9-4) | 34 | at OVC |
| vs East Tennessee St | vs Other Opponents | East Tennessee St compared to OOs | |
| Record: | 4-8 | 58-65 | |
| Points Scored: | 26.42 | 28.83 | 2.41 |
| Points Allowed: | 26.00 | 31.20 | -5.20 |
| Margin: | 0.42 | -2.37 | -2.79 |
| Total Points: | 52.42 | 60.03 | -7.61 |