| 8/30/2018 | Morehead State (3-8) | 23 | at | Eastern Kentucky | 49 | Pio | ||
| 9/8/2018 | Eastern Kentucky | 16 | at | Marshall (9-4) | 32 | at CUSA | ||
| 9/15/2018 | Eastern Kentucky | 35 | at | Bowling Green (3-9) | 42 | at MAC | ||
| 9/22/2018 | SE Missouri State (9-4,6-2) | 14 | at | Eastern Kentucky | 23 | |||
| 10/6/2018 | Jacksonville State (9-4,7-1) | 56 | at | Eastern Kentucky | 7 | |||
| 10/13/2018 | Eastern Kentucky | 35 | at | Tennessee-Martin (2-9,2-6) | 34 | |||
| 10/20/2018 | Murray State (5-6,5-3) | 34 | at | Eastern Kentucky | 6 | |||
| 10/27/2018 | Eastern Illinois (3-8,3-5) | 23 | at | Eastern Kentucky | 31 | |||
| 11/3/2018 | Eastern Kentucky | 17 | at | Austin Peay (5-6,3-5) | 13 | |||
| 11/10/2018 | Robert Morris (2-9) | 39 | at | Eastern Kentucky | 40 | OT | NE | |
| 11/17/2018 | Eastern Kentucky | 37 | at | Tennessee Tech (1-10,1-7) | 6 |
| vs Eastern Kentucky | vs Other Opponents | Eastern Kentucky compared to OOs | |
| Record: | 4-7 | 47-70 | |
| Points Scored: | 28.73 | 29.39 | 0.66 |
| Points Allowed: | 26.91 | 35.88 | -8.97 |
| Margin: | 1.82 | -6.49 | -8.31 |
| Total Points: | 55.64 | 65.27 | -9.63 |