| 8/30/2018 | Southern Illinois (2-9) | 49 | at | Murray State | 10 | MVC | ||
| 9/8/2018 | Murray State | 13 | at | Central Arkansas (6-5) | 26 | at SLC | ||
| 9/15/2018 | Murray State | 10 | at | Kentucky (10-3) | 48 | at SEC | ||
| 9/29/2018 | Tennessee-Martin (2-9,2-6) | 38 | at | Murray State | 45 | |||
| 10/6/2018 | Murray State | 48 | at | Eastern Illinois (3-8,3-5) | 41 | |||
| 10/13/2018 | Tennessee State (4-5,3-4) | 21 | at | Murray State | 45 | |||
| 10/20/2018 | Murray State | 34 | at | Eastern Kentucky (7-4,5-2) | 6 | |||
| 10/27/2018 | Jacksonville State (9-4,7-1) | 42 | at | Murray State | 15 | |||
| 11/3/2018 | Murray State | 24 | at | Tennessee Tech (1-10,1-7) | 27 | |||
| 11/10/2018 | SE Missouri State (9-4,6-2) | 38 | at | Murray State | 40 | |||
| 11/17/2018 | Murray State | 23 | at | Austin Peay (5-6,3-5) | 48 |
| vs Murray State | vs Other Opponents | Murray State compared to OOs | |
| Record: | 6-5 | 52-62 | |
| Points Scored: | 34.91 | 29.95 | -4.96 |
| Points Allowed: | 27.91 | 31.97 | -4.06 |
| Margin: | 7.00 | -2.02 | -9.02 |
| Total Points: | 62.82 | 61.92 | 0.90 |