| 9/1/2018 | Jackson State (5-5) | 7 | at | Southern Miss | 55 | SWAC (1AA) | ||
| 9/8/2018 | UL Monroe (6-6) | 21 | at | Southern Miss | 20 | SBC | ||
| 9/15/2018 | Southern Miss | at | Appalachian State (11-2) | PPD | at SBC | |||
| 9/22/2018 | Rice (2-11,1-7) | 22 | at | Southern Miss | 40 | |||
| 9/29/2018 | Southern Miss | 13 | at | Auburn (8-5) | 24 | at SEC | ||
| 10/13/2018 | Southern Miss | 7 | at | North Texas (9-4,5-3) | 30 | |||
| 10/20/2018 | Texas-San Antonio (3-9,2-6) | 17 | at | Southern Miss | 27 | |||
| 10/27/2018 | Southern Miss | 17 | at | UNC-Charlotte (5-7,4-4) | 20 | |||
| 11/3/2018 | Marshall (9-4,6-2) | 24 | at | Southern Miss | 26 | |||
| 11/10/2018 | Southern Miss | 23 | at | UAB (11-3,8-1) | 26 | OT | ||
| 11/17/2018 | Louisiana Tech (8-5,5-3) | 20 | at | Southern Miss | 21 | |||
| 11/24/2018 | Southern Miss | 39 | at | UTEP (1-11,1-7) | 7 |
| vs Southern Miss | vs Other Opponents | Southern Miss compared to OOs | |
| Record: | 5-6 | 73-66 | |
| Points Scored: | 19.82 | 25.88 | 6.06 |
| Points Allowed: | 26.18 | 25.01 | 1.17 |
| Margin: | -6.36 | 0.87 | 7.23 |
| Total Points: | 46.00 | 50.89 | -4.89 |