| 8/30/2018 | Wake Forest | 23 | at | Tulane (7-6) | 17 | OT | at AAC | |
| 9/8/2018 | Towson (7-5) | 20 | at | Wake Forest | 51 | CAAF (1AA) | ||
| 9/13/2018 | Boston College (7-5,4-4) | 41 | at | Wake Forest | 34 | |||
| 9/22/2018 | Notre Dame (12-1) | 56 | at | Wake Forest | 27 | ND | ||
| 9/29/2018 | Rice (2-11) | 24 | at | Wake Forest | 56 | CUSA | ||
| 10/6/2018 | Clemson (15-0,9-0) | 63 | at | Wake Forest | 3 | |||
| 10/20/2018 | Wake Forest | 17 | at | Florida State (5-7,3-5) | 38 | |||
| 10/27/2018 | Wake Forest | 56 | at | Louisville (2-10,0-8) | 35 | |||
| 11/3/2018 | Syracuse (10-3,6-2) | 41 | at | Wake Forest | 24 | |||
| 11/8/2018 | Wake Forest | 27 | at | North Carolina State (9-4,5-3) | 23 | |||
| 11/17/2018 | Pittsburgh (7-7,6-3) | 34 | at | Wake Forest | 13 | |||
| 11/24/2018 | Wake Forest | 59 | at | Duke (8-5,3-5) | 7 | |||
| 12/22/2018 | Memphis (8-6) | 34 | vs | Wake Forest | 37 | BIRMINGHAM BOWL - Birmingham AL | AAC |
| vs Wake Forest | vs Other Opponents | Wake Forest compared to OOs | |
| Record: | 6-7 | 93-63 | |
| Points Scored: | 33.31 | 31.01 | -2.30 |
| Points Allowed: | 32.85 | 27.31 | 5.54 |
| Margin: | 0.46 | 3.70 | 3.24 |
| Total Points: | 66.16 | 58.32 | 7.84 |