| 9/1/2018 | South Dakota State (10-3) | at | Iowa State | CCD | MVC (1AA) | |||
| 9/8/2018 | Iowa State | 3 | at | Iowa (9-4) | 13 | at B10 | ||
| 9/15/2018 | Oklahoma (12-2,9-1) | 37 | at | Iowa State | 27 | |||
| 9/22/2018 | Akron (4-8) | 13 | at | Iowa State | 26 | MAC | ||
| 9/29/2018 | Iowa State | 14 | at | TCU (7-6,4-5) | 17 | |||
| 10/6/2018 | Iowa State | 48 | at | Oklahoma State (7-6,3-6) | 42 | |||
| 10/13/2018 | West Virginia (8-4,6-3) | 14 | at | Iowa State | 30 | |||
| 10/27/2018 | Texas Tech (5-7,3-6) | 31 | at | Iowa State | 40 | |||
| 11/3/2018 | Iowa State | 27 | at | Kansas (3-9,1-8) | 3 | |||
| 11/10/2018 | Baylor (7-6,4-5) | 14 | at | Iowa State | 28 | |||
| 11/17/2018 | Iowa State | 10 | at | Texas (10-4,7-3) | 24 | |||
| 11/24/2018 | Kansas State (5-7,3-6) | 38 | at | Iowa State | 42 | |||
| 12/1/2018 | Drake (7-4) | 24 | at | Iowa State | 27 | Pio (1AA) | ||
| 12/28/2018 | Iowa State | 26 | vs | Washington State (11-2) | 28 | VALERO ALAMO BOWL - San Antonio TX | vs P12 |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 5-8 | 100-64 | |
| Points Scored: | 22.92 | 33.47 | 10.55 |
| Points Allowed: | 26.77 | 26.45 | 0.32 |
| Margin: | -3.85 | 7.02 | 10.87 |
| Total Points: | 49.69 | 59.92 | -10.23 |