| 8/30/2018 | Missouri State (4-7) | 17 | at | Oklahoma State | 58 | MVC (1AA) | ||
| 9/8/2018 | South Alabama (3-9) | 13 | at | Oklahoma State | 55 | SBC | ||
| 9/15/2018 | Boise State (10-3) | 21 | at | Oklahoma State | 44 | MW | ||
| 9/22/2018 | Texas Tech (5-7,3-6) | 41 | at | Oklahoma State | 17 | |||
| 9/29/2018 | Oklahoma State | 48 | at | Kansas (3-9,1-8) | 28 | |||
| 10/6/2018 | Iowa State (8-5,6-3) | 48 | at | Oklahoma State | 42 | |||
| 10/13/2018 | Oklahoma State | 12 | at | Kansas State (5-7,3-6) | 31 | |||
| 10/27/2018 | Texas (10-4,7-3) | 35 | at | Oklahoma State | 38 | |||
| 11/3/2018 | Oklahoma State | 31 | at | Baylor (7-6,4-5) | 35 | |||
| 11/10/2018 | Oklahoma State | 47 | at | Oklahoma (12-2,9-1) | 48 | |||
| 11/17/2018 | West Virginia (8-4,6-3) | 41 | at | Oklahoma State | 45 | |||
| 11/24/2018 | Oklahoma State | 24 | at | TCU (7-6,4-5) | 31 | |||
| 12/31/2018 | Missouri (8-5) | 33 | vs | Oklahoma State | 38 | AUTOZONE LIBERTY BOWL - Memphis | SEC |
| vs Oklahoma State | vs Other Opponents | Oklahoma State compared to OOs | |
| Record: | 6-7 | 84-67 | |
| Points Scored: | 32.46 | 31.09 | -1.37 |
| Points Allowed: | 38.38 | 27.70 | 10.68 |
| Margin: | -5.92 | 3.39 | 9.31 |
| Total Points: | 70.84 | 58.79 | 12.05 |