| 9/1/2016 | Kentucky Wesleyan | 29 | at | Delta State (4-6) | 50 | at GSC | ||
| 9/10/2016 | Davidson (2-9) | 35 | at | Kentucky Wesleyan | 21 | Pio (1AA) | ||
| 9/17/2016 | Kentucky Wesleyan | 7 | at | Davenport (5-5) | 41 | at NAIAInd | ||
| 9/24/2016 | Indianapolis (6-5) | 37 | at | Kentucky Wesleyan | 7 | GLV | ||
| 10/1/2016 | Central State (1-9) | 7 | at | Kentucky Wesleyan | 21 | SIAC | ||
| 10/8/2016 | Kentucky Wesleyan | 7 | at | Northwestern State (1-10) | 49 | at SLC | ||
| 10/15/2016 | Kentucky Wesleyan | 20 | at | UNC Pembroke (10-2,2-0) | 43 | |||
| 10/22/2016 | Ashland (9-2) | 70 | at | Kentucky Wesleyan | 14 | GLIAC | ||
| 10/29/2016 | Kentucky Wesleyan | 52 | at | Alfred State (1-8) | 7 | at D3Ind | ||
| 11/5/2016 | Malone (1-8) | 30 | at | Kentucky Wesleyan | 40 | GLIAC | ||
| 11/12/2016 | Kentucky Wesleyan | 28 | at | Alderson-Broaddus (7-2,1-0) | 31 |
| vs Kentucky Wesleyan | vs Other Opponents | Kentucky Wesleyan compared to OOs | |
| Record: | 8-3 | 39-63 | |
| Points Scored: | 36.36 | 24.14 | -12.22 |
| Points Allowed: | 22.36 | 27.76 | -5.40 |
| Margin: | 14.00 | -3.62 | -17.62 |
| Total Points: | 58.72 | 51.90 | 6.82 |