| 9/3/2016 | Alabama State (4-7) | 13 | at | Texas-San Antonio | 26 | SWAC (1AA) | ||
| 9/10/2016 | Texas-San Antonio | 14 | at | Colorado State (7-6) | 23 | at MW | ||
| 9/16/2016 | Arizona State (5-7) | 32 | at | Texas-San Antonio | 28 | P12 | ||
| 9/24/2016 | Texas-San Antonio | 19 | at | Old Dominion (10-3,7-1) | 33 | |||
| 10/8/2016 | Southern Miss (7-6,4-4) | 32 | at | Texas-San Antonio | 55 | |||
| 10/15/2016 | Texas-San Antonio | 14 | at | Rice (3-9,2-6) | 13 | |||
| 10/22/2016 | UTEP (4-8,2-6) | 52 | at | Texas-San Antonio | 49 | 5OT | ||
| 10/29/2016 | North Texas (5-8,3-5) | 17 | at | Texas-San Antonio | 31 | |||
| 11/5/2016 | Texas-San Antonio | 45 | at | Middle Tenn State (8-5,5-3) | 25 | |||
| 11/12/2016 | Texas-San Antonio | 35 | at | Louisiana Tech (9-5,6-3) | 63 | |||
| 11/19/2016 | Texas-San Antonio | 10 | at | Texas A&M (8-5) | 23 | at SEC | ||
| 11/26/2016 | UNC-Charlotte (4-8,3-5) | 14 | at | Texas-San Antonio | 33 | |||
| 12/17/2016 | New Mexico (9-4) | 23 | vs | Texas-San Antonio | 20 | Gildan New Mexico Bowl (Albuquerque NM) | MW |
| vs Texas-San Antonio | vs Other Opponents | Texas-San Antonio compared to OOs | |
| Record: | 7-6 | 76-75 | |
| Points Scored: | 27.92 | 32.94 | 5.02 |
| Points Allowed: | 29.15 | 32.46 | -3.31 |
| Margin: | -1.23 | 0.48 | 1.71 |
| Total Points: | 57.07 | 65.40 | -8.33 |