D2
9 Feb 2017 19:37:20
| 9/1/2016 | Angelo State | 19 | at | McKendree | 33 | | | LSC |
| Eastern New Mexico | 35 | at | Southwest Baptist | 49 | | | LSC |
| 9/3/2016 | Quincy | 38 | at | Drake | 35 | | | @ Pio (1AA) |
| Indianapolis | 24 | at | Hillsdale | 30 | | | @ GLIAC |
| Langston | 23 | at | Lincoln MO | 13 | | | CSFL (NAIA) |
| Bacone | 14 | at | Missouri S&T | 62 | | | CSFL (NAIA) |
| William Jewell | 41 | at | South Dakota Tech | 64 | | | @ GNWAC |
| Edinboro | 31 | at | St Joseph's | 30 | | | PSAC |
| Midwestern State | 31 | at | Truman State | 19 | | | LSC |
| 9/10/2016 | Marian IN | 38 | at | Indianapolis | 16 | | | MSFA (NAIA) |
| Lincoln MO | 23 | at | Lincoln PA | 33 | | | @ CIAA |
| West Liberty | 15 | at | McKendree | 16 | OT | | MtnE |
| Mayville State | 7 | at | Quincy | 64 | | | NSAA (NAIA) |
| Alderson-Broaddus | 6 | at | St Joseph's | 13 | | | D2Ind |
| Southwest Baptist | 31 | at | Tarleton State | 28 | | | @ LSC |
| Malone | 3 | at | Truman State | 35 | | | GLIAC |
| Missouri S&T | 28 | at | West Florida | 45 | | | @ GSC |
| Doane | 23 | at | William Jewell | 12 | | | GPAC (NAIA) |
| 9/17/2016 | McKendree | 16 | at | Drake | 28 | | | @ Pio (1AA) |
| Quincy | 40 | at | Lincoln MO | 14 | | | |
| Truman State | 44 | at | Missouri S&T | 20 | | | |
| Indianapolis | 37 | at | Southwest Baptist | 41 | | | |
| St Joseph's | 31 | at | William Jewell | 26 | | | |
| 9/24/2016 | Indianapolis | 37 | at | Kentucky Wesleyan | 7 | | | @ D2Ind |
| William Jewell | 14 | at | McKendree | 28 | | | |
| Southwest Baptist | 37 | at | Quincy | 20 | | | |
| Missouri S&T | 54 | at | St Joseph's | 21 | | | |
| Lincoln MO | 0 | at | Truman State | 37 | | | |
| 10/1/2016 | Lane | 9 | at | Lincoln MO | 12 | | | SIAC |
| William Jewell | 0 | at | Missouri S&T | 26 | | | |
| Quincy | 13 | at | St Joseph's | 31 | | | |
| McKendree | 7 | at | Southwest Baptist | 35 | | | |
| Indianapolis | 17 | at | Truman State | 24 | | | |
| 10/8/2016 | McKendree | 24 | at | Indianapolis | 34 | | | |
| Missouri S&T | 16 | at | Kennesaw St | 49 | | | @ BigS (1AA) |
| St Joseph's | 27 | at | Lincoln MO | 17 | | | |
| Truman State | 26 | at | Southwest Baptist | 16 | | | |
| Quincy | 55 | at | William Jewell | 14 | | | |
| 10/15/2016 | Truman State | 3 | at | Grand Valley State | 41 | | | @ GLIAC |
| St Joseph's | 16 | at | McKendree | 20 | | | |
| Lincoln MO | 16 | at | Missouri S&T | 65 | | | |
| Indianapolis | 20 | at | Quincy | 33 | | | |
| Southwest Baptist | 51 | at | William Jewell | 28 | | | |
| 10/22/2016 | Quincy | 10 | at | Davenport | 14 | | | @ NAIAInd (NAIA) |
| Lincoln MO | 7 | at | Indianapolis | 38 | | | |
| Missouri S&T | 7 | at | McKendree | 40 | | | |
| Southwest Baptist | 61 | at | St Joseph's | 37 | | | |
| William Jewell | 24 | at | Truman State | 31 | | | |
| 10/29/2016 | St Joseph's | 24 | at | Davenport | 20 | | | @ NAIAInd (NAIA) |
| William Jewell | 12 | at | Indianapolis | 34 | | | |
| McKendree | 55 | at | Lincoln MO | 3 | | | |
| Missouri S&T | 22 | at | Southwest Baptist | 45 | | | |
| Quincy | 28 | at | Truman State | 38 | | | |
| 11/5/2016 | Southwest Baptist | 54 | at | Central State | 34 | | | @ SIAC |
| Indianapolis | 16 | at | Missouri S&T | 6 | | | |
| McKendree | 35 | at | Quincy | 17 | | | |
| Truman State | 23 | at | St Joseph's | 3 | | | |
| Lincoln MO | 17 | at | William Jewell | 48 | | | |
| 11/12/2016 | St Joseph's | 16 | at | Indianapolis | 21 | | | |
| Southwest Baptist | 50 | at | Lincoln MO | 12 | | | |
| Truman State | 14 | at | McKendree | 41 | | | |
| Missouri S&T | 24 | at | Quincy | 20 | | | |
| 11/19/2016 | Colorado Mines | 63 | at | Southwest Baptist | 35 | | | RMAC |